Effect and Mechanism of Marein on Diabetic Retinopathy
Effect and Mechanism of Marein on Diabetic Retinopathy
Zhipeng Song1,2, Jialiang Xin1,3, Xiaoli Wei1,2, Abula Zulipiya1,3, Kadier Kedireya1,2 and Xinmin Mao1,3*
A: Immunohistochemical staining of VEGF-A and SYK in experimental mice retinal tissue (200×). Note: The values were expressed as `x ± SEM, n ≥ 6, *P < 0.05, **P < 0.01 indicated statistical significance compared with the control group. #P < 0.05, ##P < 0.01 indicated statistical significance compared with the model group; B: Effect of Marein on mRNA levels of retinopathy related proteins in retinal tissue of db/db mice. Note: The values were expressed as `x ± SEM, n ≥ 6, *P < 0.05, **P < 0.01 indicated statistical significance compared with the control group. #P < 0.05, ##P < 0.01 indicated statistical significance compared with the model group.
A: Effect of high glucose on cell morphology and quantity. B: Effects of high glucose and marein on cell viability. *P < 0.05, **P < 0.01, ***P < 0.001.
Effect of marein on protein expression in ARPE-19 cells treated with high glucose. Note: *P < 0.05, **P < 0.01 indicated statistical significance compared with the control group. #P < 0.05, ##P < 0.01 indicated statistical significance compared with the model group.
