Correlation of Serum Pentraxin 3, Apelin and sRAGE with Obesity and Glycolipid Metabolism in Polycystic Ovary Syndrome
Correlation of Serum Pentraxin 3, Apelin and sRAGE with Obesity and Glycolipid Metabolism in Polycystic Ovary Syndrome
Yanxi Li1, Yong Huang1*, Jun Peng1*, Yicun Man2, Yaqi Li1, Erqing Peng1,
Xin Wen1, Xi Yang1 and Li Hong1
ABSTRACT
The objective of this study was to analyze the correlation of serum PTX3, apelin and sRAGE with obesity and glycolipid metabolism in polycystic ovary syndrome (PCOS). The sample of 82 PCOS patients was divided into the overweight subgroup and normal weight subgroup according to the BMI of all subjects. The morning fasting venous blood of all subjects was collected and detected by radioimmunoassay. The levels of apelin, PTX3 and sRAGE, FPG, fins, TC, LDL-C, TG, and HDL-C were detached using enzyme-linked immunosorbent assay and HOMA was calculated -IR. Spearman was used to analyzing the correlation of PTX3, apelin and sRAGE with obesity and glycolipid metabolism in PCOS patients. PTX3 and sRAGE were decreased while the levels of apelin were raised than normal weight subgroups. The levels of PTX3 and sRAGE were reduced than those of control subgroups, and the levels of apelin were raised than those of control subgroups. The levels of fins, FPG, HOMA-IR and WHR in obesity subgroups of each group were raised than those in normal weight subgroups of the same group; the levels of fins, FPG and HOMA-IR in obesity subgroups of each group were raised than those in control subgroups. The levels of TG and LDL-C were higher than those of the normal weight subgroups. Spearman analysis showed that PTX3 and sRAGE were negatively correlated with fins, FPG, HOMA-IR and BMI, and apelin was positively correlated with fins, FPG, HOMA-IR and BMI, and negatively correlated with HDL-C. It was concluded that apelin and sRAGE in PCOS patients is related to obesity and glycolipid metabolism, which may be closely related to the progress of PCOS patients.
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