Comparative Molecular Analysis of Isolated Strains of Highly Pathogenic Avian Influenza Virus H5N1 during 2006 and 2007
Comparative Molecular Analysis of Isolated Strains of Highly Pathogenic Avian Influenza Virus H5N1 during 2006 and 2007
Madbouly, H.M; Orkhan, M.H**; Nagwa El-khoty
ABSTRACT
Highly pathogenic avian influenza (Al) H5N1 strains have been isolated during February 2006 from infected chicken located at El-Qanater El-Khiria center, Qaluobia, Eypt. These isolates were molecularly characterized and compared with those H5Nl strains isolated during January 2007 from the same locality. The strains isolated from infected chicken during 2006 were closely related to A/ty/Turkey/l/05 strain which had been isolated from turkeys in Turkey 2005 and to MVietnam/1194/04 strain isolated from human cases of Al H5Nl and induced higher case fatality in human in Viet Nam. phylogenetic analysis of haemagglutinin (HA) and neuraminidase (NA). genes of 2006 strains revealed that these isolates are located in Euro•Asio-African lineage which contains Al H5Nl strains from Egypt, Turkey, Romania, Iraq, Mongolia, Iran, Korea and Nigeria and differed from those strains isolated in South-Eastern of Asia which contains Cambodia, Thailand, and Viet Nam Al H5Nl strains. The phylogenetic analysis of HA, NA, and Matrix (M) genes of Egyptian isolates of January 2007 from the same locality showed minor antigenic variation from those of 2006 and have been located in a new sub-clade from the Egyptian strains of 2006 and all of them are located together in the Euro-African lineage.
To share on other social networks, click on any share button. What are these?
July 2008
Vol. 5, Iss. 1
