Changes in Serum Endothelin, Brain Natriuretic Peptide and High Sensitive C-Reactive Protein Levels in Patients with Coronary Heart Disease
Changes in Serum Endothelin, Brain Natriuretic Peptide and High Sensitive C-Reactive Protein Levels in Patients with Coronary Heart Disease
Zheng Tan*, Li Li, Yuxin Song, Meirong Tian and Fan Jia
ABSTRACT
In this study, 150 patients diagnosed with coronary heart disease (CHD) were divided them into three groups, each containing 50 patients, namely stable angina pectoris (SAP) group, unstable angina pectoris (UAP) group, and acute myocardial infarction (AMI) group. Fifth healthy people were enrolled as control. The changes in serum endothelin, brain natriuretic peptide and high sensitive c-reactive protein in patients with CHD were observed and analyzed. The levels of serum endothelin, brain natriuretic peptide and high-sensitivity c-reactive protein were significantly higher in AMI group compared to UAP group, SAP group and the control group, p<0.05. The level of indicators in the UAP group was higher than that in the SAP group and the control group, p<0.05. Compared with the control group, all indicators in SAP group were significantly higher, p<0.05. The serum endothelin, brain natriuretic peptide and high sensitive c-reactive protein levels were significantly increased during the clinical diagnosis of CHD, which indicates that these three indicators play a key role in the pathogenesis and can be used as indicators for clinical risk stratification of CHD.
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