Cerebrospinal Fluid τ Protein Expression is Correlated with DTI Quantification in Leukoaraiosis Patients
Cerebrospinal Fluid τ Protein Expression is Correlated with DTI Quantification in Leukoaraiosis Patients
Longjun Guo*, Jiaqi Teng, Juan Wang and Yukun Chen
ABSTRACT
This study was aimed to investigate the relationship between diffusion tensor imaging (DTI) quantification and cerebrospinal fluid τ (Tau) protein expression in leukoaraiosis patients. Inpatients who attended the Department of Neurology of our hospital from January 2018 to December 2018 were selected as study subjects, with 58 patients with leukoarais as the experimental group, and 60 patients without leukoarais in the same period as the control group. ELISA was used to detect τ (Tau) protein expression level in the cerebrospinal fluid of the two groups. DTI technique was taken to compare DTI anisotropic diffusion coefficients of the two groups. According to our results there was a statistically significant difference in cerebrospinal fluid Tau protein concentration between the experimental group and the control group (P<0.05), and there was no statistically significant difference in CSF IgG index between the experimental group and the control group (P>0.05). DTI was used to process diffusion tensor data and visually and clearly display the distribution and metastasis of brain nerve fibers or white matter. In terms of leukoaraiosis degree, FA decreased. Where, DR increased, AMO decreased, Dave and DAx remained unchanged. Most FA reduction observed in white matter was observed in the corpus callosum. In the end we concluded τ protein expression in cerebrospinal fluid can enable identification of the occurrence of LA symptoms to a certain extent. Its combined use with DTI, an important tool for non-invasive analysis of the internal brain structure, is playing an increasingly important role in medical clinical and basic research.
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April 2022
Vol. 54, Iss. 2, Pages 503-1000
