Cardiac Stem Cells at a Glance
Cardiac Stem Cells at a Glance
Jiao Ma*
ABSTRACT
Myocardial cell loss is hypothesized to be irreversible but latest research indicates that human cardiac stem cells (hCSCs) may have a therapeutic use for cardiac repair; however, their properties and the regulatory mechanisms for their development have not been thoroughly explored. Stem cells are a population of cells with the potential for self-regeneration and differentiation into cell types that can play an important role in embryogenesis and embryonic development. So far, seven types of cardiac stem cells with different molecular phenotypes and differentiation potentials have been discovered and studied. Increased proliferation and differentiation of these cells in areas of cardiac ischemia is a significant factor in the repair and enhancement of heart injury. This role of endogenic cardiac stem cells can be regulated by factors. Numerous causes, such as paracrine and autocrine factors, extracellular matrixes and genetic factors. In general, it is well known that these variables could have an appropriate role to improve the effectiveness of the treatment of heart lesions. The work of cytokines and growth factors has been found to play an important role in increasing endogenous cardiac stem cell proliferation and migration capacity. One of the successful approaches is to use these factors along with cardiac stem cells to boost the repair efficiency of heart injury. Therefore, in the present review study, the types of cardiac stem cells and their molecular phenotype, cardiac stem cell genetics and their ability to treat heart injury have been studied. Understanding the molecular processes and messaging pathways involved in success Cardiac stem cells offer an effective approach to the production and presentation of cardiac lesion therapy using cardiac stem cells.
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