Biochemical Profiling of Arsenic Trioxide-Induced Impaired Carbohydrate Metabolism and its Therapeutic Intervention via Modulation of Metabolic Pathways
Biochemical Profiling of Arsenic Trioxide-Induced Impaired Carbohydrate Metabolism and its Therapeutic Intervention via Modulation of Metabolic Pathways
Muhammad Sajid Hamid Akash1*, Hina Sharif1, Kanwal Rehman2, Sumbal Rasheed1 and Shagufta Kamal3
Fig. 1.
Effect of ATO on serum insulin (A), insulin resistance (B), bloood glucose level (C) and HbA1c level (D). Significance was estimated by Bonferroni post-test using one way ANOVA. * represents P < 0.05, ** represents P < 0.01 and ns represents non-significant when compared with NC group. ATO, arsenic trioxide group; HbA1c, hemoglobin A1c; MF, metformin group; NC, normal control group; RSV, resveratrol group.
Fig. 2.
Effect of ATO on activities of α-amylase (A), α-glucosidase (B), hexokinase (C) and G6PC (D).
For statistical details and abbreviations, see Figure 1.
Fig. 3.
Arsenic concentration in the liver sample is detected by HG-AAS. For statistical details and abbreviations, see Figure 1. *** represents P < 0.001 when compared with NC group. As, arsenic; HG-AAS, hydride generation atomic absorption spectroscopy.
December 2022
Vol. 54, Iss. 6, Pages 2501-3000
