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Bax and CD68 Expression in Response to Liver Injury Induced by Acetaminophen: The Hepatoprotective Role of Thymoquinone and Curcumin

Bax and CD68 Expression in Response to Liver Injury Induced by Acetaminophen: The Hepatoprotective Role of Thymoquinone and Curcumin

Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1

1Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia. 

2Department of Genetics and Cytology, National Research Center, Dokki, Egypt.

3Preparatory Year Deanship, King Saud University, Riyadh, Kingdom of Saudi Arabia.

4Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.

5Anatomy Department, Faculty of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

*Corresponding author: hsameh2312003@yahoo.com

 

Figure 1

 Serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and hepatic malondialdehyde (MDA), reduced glutathione (GSH) and superoxide (SOD) in control (CON) and all experimental groups

Figure 2

Histological investigation ofrat’s lever stained at H&E.

Figure 3

Histological examination of rat’s liver stained by Masson’s Trichrome.

Figure 4

Histological investigation of rat’s liver stained by Immuno-stain with the anti CD68 antibody.

Figure 5

Histological investigation of rat’s liver stained by Immuno-stain with the anti-Bax antibody.

Pakistan Journal of Zoology

October

Pakistan J. Zool., Vol. 56, Iss. 5, pp. 2001-2500

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