Association of Types of Overlapping Genes with the Size of Chromosome in Human Genome
Association of Types of Overlapping Genes with the Size of Chromosome in Human Genome
Syed Kashif Nawaz*, Faiza Zubair and Sidra Kanwal
ABSTRACT
Overlapping genes are an integral component of the genome. The present study investigated the various types of overlapping genes in human genome. Study was completed using genome assembly GRCh 38/ hg38 data was accessed using NCBI map viewer for the identification of exact loci of overlapping genes. It was noticed that maximum number (635) of overlapping genes were present on chromosome 1. Chromosome 21 carried the minimum number (85) of overlapping genes. Overlapping genes were further categorized on the basis of their orientation. It was found that the human genome has 62% embedded genes, 17% convergent genes, 16% divergent genes and 5% uni-directional genes. These categories may further be differentiated as coding vs. coding, coding vs. non-coding and mixture of both types on the basis of overlapping gene structure. Our analyses revealed that human genome has various types of overlapping genes. The occurrence of these overlapping genes is not solely dependent on the size of the chromosomes.
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April 2018
Vol. 50, Iss. 2, Pages 401-797
