Analysis of Risk Factors of Cartilage Wear in Lateral Compartment of Patients with Varus Knee Osteoarthritis
Analysis of Risk Factors of Cartilage Wear in Lateral Compartment of Patients with Varus Knee Osteoarthritis
Ying Li, Peng Zhan, Qiang Wang and Dongfeng Chen*
ABSTRACT
The objective of this study was to investigate the risk factors of cartilage wear in the lateral compartment of patients with varus knee osteoarthritis (VKO). The sample consisted of 110 patients with VKO who underwent total knee arthroplasty at Fujian hospital. The patients were divided into the lateral compartment cartilage abrasion group (n=30) and the lateral compartment cartilage non abrasion group (n=80) according to the lateral compartment cartilage status. The clinical data and laboratory indexes of patients were collected, and the risk factors of cartilage wear in lateral compartment of patients with VKO were analyzed by single factor and multi factor logistic regression. Labor intensity, imaging grade, integrity of lateral meniscus and anterior cruciate ligament, and course of disease may be the risk factors for cartilage wear of lateral compartment in patients with VKO (P<0.05). The levels of IL-6, TNF-α and IL-1β in the joint fluid of the cartilage wear group were significantly higher than those of the non-wear group (P<0.05). The results showed that the heavy labor intensity, the absence or insufficiency of the lateral meniscus, the absence or insufficiency of the anterior cruciate ligament, the long course of disease, and the high level of IL-6, TNF-α and IL-1β was an independent risk factor for cartilage wear of lateral compartment in patients with VKO (P<0.05). It was concluded that heavy labor intensity, absence or incompleteness of lateral meniscus, absence or incompleteness of anterior cruciate ligament, long course of disease and high level of IL-6 and TNF-α in synovial fluid IL-1β Level is an independent risk factor for cartilage wear of lateral compartment in patients with VKO.
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