Submit or Track your Manuscript LOG-IN

A New Species of the Genus Otacilia

Otacilia dadongshanica sp. nov., male holotype.

A New Species of the Genus Otacilia

Otacilia dadongshanica sp. nov., male holotype.

A Homozygous c.2536G-to-A Mutation in CRB1 Gene Manifesting Autosomal Recessive Retinitis Pigmentosa in a Large Consanguineous Kashmiri Family

A Homozygous c.2536G-to-A Mutation in CRB1 Gene Manifesting Autosomal Recessive Retinitis Pigmentosa in a Large Consanguineous Kashmiri Family

Zahid Latif1,*, Kathrin Blasius2-4, Tufail Hussain Tahir7, Muhammad Nasim Khan1, Ghazanfar Ali5, Ansar Ahmed Abbasi6, Abdul Rauf1, Hao Hu8 and Angela M. Kaindl2,3,4

ABSTRACT

Retinitis pigmentosa (RP) is the condition of visual impairment which has most feared impact on blind individuals and family. As the cheerful life is made possible by illumination of sight similarly on opposite, blindness snatch this beauty of life and push the sufferers to unending darkness which also has a negative social and economic wellbeing impact on individual’s life. In society, the negative impact of visual impairment is the rejection and exclusion from all healthy activities of life. Patients suffering with RP first experience nyctalopia which gradually progress to tunnel vision and ultimately masks with complete blindness. Autosomal recessive mode of inheritance which contributes 20-25% of total known cases of RP, is almost the result of inbreed union or cousin marriages. In this study, a large consanguineous family with 11 affected individuals was recruited from Azad Jammu and Kashmir which was analyzed through linkage mapping and confirmed by Sanger sequencing. This family showed a homozygous c.2536G>A mutation in CRB1 gene as an underlying pathogenic variant for non-syndromic autosomal recessive retinitis pigmentosa.

To share on other social networks, click on any share button. What are these?

Pakistan Journal of Zoology

November

Pakistan J. Zool., Vol. 56

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe