Use of Cymelarsan and Manganese Chloride for Treatment of the Canine <i>Trypanosomiasis</i> (Surra): A Research report

Imaad Rashid¹, Sehrish Firyal², Arslan Tariq^3*, Ghulam Muhammad¹, Muhammad Saqib¹, Muhammad Shoaib Zafar^4
1Department of Clinical Medicine and Surgery, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan; ²Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan; ³Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan; ⁴Department of Physiology and Pharmacology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan
*Corresponding author: dr.arslantariq3418@live.com

ABSTRACT
The present report describes a case of Trypanosoma evansi infection (surra) in a 5 months old male bulldog pup weighing 13 kg. Clinical signs included a moderate fever (39.6oC), pulse (140 beats/min) and an accelerated respiration rate (45/min; normal 10–30/min), anemia, watery eyes and dehydration. Microscopic examination of wet blood films revealed an extremely large number of trypo-mastigotes and thin blood smears stained with Dip Quick™ stain revealed a large numbers of trypanosomes with a characteristic flagellum, kinetoplast and undulating membrane. The pup was treated with 4 mg Cymelarsan® (Rhone Meriux, France) powder dissolved in 3 ml distilled water and administered by deep intramuscular injection once and oral administration of 100 mg manganese chloride dissolved in 10 ml water daily for 5 days. Wet blood films and Dip Quick™ stained blood smears were negative for trypanosomes on day 3, 7, and 14 of post treatment and all vital parameters returned to normal on day–4 post–medication.

Key Words: Canine, Trypanosoma evansi (Surra), Dip Quick™ stain, Cymelarsan®, Manganese chloride,