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Case Report · Volume 2, Issue 3, Pages 65–68, 22 November 2015 · Open Access

Human Asian Trypanosomiasis due to <i>Trypanosoma</i> <i>evansi</i>: A Rare Case

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Article Info ⌄
Journal:
The Journal of Advances in Parasitology
Published:
22 November 2015
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From the article

  • Though human serum is lethal to Trypanosma evansi, but because the patient was immunocompromised, hence this species led to disease with teaming parasitaemia.
  • Keywords | Human Asian Trypanosomiasis, Trypanosoma evansi, Retroviral disease, Suramin.
  • Human trypanosomiasis caused by Trypanosoma evansi in India: The first case report.
  • Human Trypanosomiasis in India: Is it an emerging new zoonosis?

Selected from the article's own text.

Abstract

Vaishali Wabale1*, Prashant Nalage2, Ameeta Joshi1, Renu Bharadwaj1, Kalpana Deshpande3, Abhay Chowdhary1

1Department of Microbiology, Grant Government Medical College, Mumbai; 2Preclinical Toxicology, Suven Life, Science, Hyderabad, Telangana; 3Department of Pathology, Grant Government Medical College, Mumbai, India.

*Correspondence | Vaishali Wabale, Grant Government Medical College & Sir J. J. Hospitals, Byculla, Mumbai, Maharashtra, India; Email: vrwabale@gmail.com

Abstract
Trypanosomes are unicellular eukaryotic haemoprotozoan parasite found worldwide. They infect humans, domestic and wild animals and are transmitted by blood-sucking insects. Here, the patient, a pregnant female, in the 28th week, a known case of retroviral disease (RVD) presented with severe anemia and upper respiratory tract infection (URTI) with tuberculous lymphadenitis. Preliminary diagnosis was made was threatened abortion with respiratory tract infection due to complaints of breathlessness on exertion, cough with expectoration, low grade fever since one month along with pain in abdomen and in ear since 15 days. The direct microscopic examination of Leishman stained PBS smear of blood revealed a flagellated form with a purple colored nucleus with a dark red kinetoplast in blue colored cytoplasm and an undulating membrane. A provisional diagnosis of Trypanosomiasis was made and confirmed when T. evansi grew on Novy- Mac Neal- Nicolle (NNN) Modified Twin pack Medium (HI MEDIA Laboratories, Mumbai). The patient responded to suramin. Though human serum is lethal to Trypanosma evansi, but because the patient was immunocompromised, hence this species led to disease with teaming parasitaemia.

Keywords | Human Asian Trypanosomiasis, Trypanosoma evansi, Retroviral disease, Suramin.

Editor | Muhammad Imran Rashid, Department of Parasitology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Received | July 23, 2015; Revised | September 13, 2015; Accepted | September 16, 2015; Published | November 22, 2015

Citation | Wabale V, Nalage P, Joshi A, Bharadwaj R, Deshpande K, Chowdhary A (2015). Human Asian trypanosomiasis due to Trypanosoma evansi: A rare case. J. Adv. Parasitol. 2(3): 65-68.

ISSN | 2311-4096

Copyright © 2015 Wabale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Acknowledgment

We thank Dr. Mukulesh L. Gatne (Professor and University Head, Department of Parasitology, Bombay Veterinary College, Parel, Mumbai, 400 012, Maharashtra).

Conflict of interest

There exixits no conflict of interest.

AUTHORS CONTRIBUTION

Vaishali Wabale acted as principal investigator and presented concept and design of the study, Prashant Nalage assisted in all microbiological investigations and eterinary investigations while Ameeta Joshi assisted in writing an article. Renu Bharadwaj assisted in culture and confirmation of parasite; Kalpana Deshpande assisted in thin and thick smear examination and Abhay Chowdhary reviewed and edited the article.

References

  1. Brun R (2005). Human Asian trypanosomiasis, A new threat to human health? Am. J. Trop. Med. Hyg. 73(3): 484.
  2. Desquesnes M, HolzMuller P, Lai D, Dargantes A, Lun Zhao-Rong, Jittaplapong S (2013). Trypanosoma evansi and Surra: A review and prospectives on origin, history, distribution, taxonomy, morphology, hosts and pathogenic effects. Biomed. Res. Int. 8: 1-28. http://dx.doi.org/10.1155/2013/194176[CrossRef]
  3. Gupta MP, Kumar H, Singla LD (2009). Trypanosomiasis concurrent to tuberculosis in black bucks. Indian Vet. J. 86: 727-728.
  4. Gutierrez C, Desquesnes M, Touratier L, Buscher P (2010). Trypanosoma evansi: recent outbreaks in Europe. Vet. Parasitol. 24(174): 26-29. http://dx.doi.org/10.1016/j.vetpar.2010.08.012[CrossRef]
  5. Joshi PP, Shegokar VR, Powar RM, Herder S, Katti R, Salkar H, Salkar HR, Dani VS, Bhargava A, Jannin J, Truc P(2005). Human trypanosomiasis caused by Trypanosoma evansi in India: The first case report. Am. J. Trop. Med. Hyg. 73: 491-95.
  6. Joshi PP (2013). Human Trypanosomiasis in India: Is it an emerging new zoonosis? 10-13 www.apiindia.org/medicine-update-2013/chapter04.pdf
  7. Juyal PD, Singla LD, Saxena HM (1998). In vivo activity of human serum against Trypanosoma evansi in Swiss albino mice. J. Parasit. Dis. 22: 67-68.
  8. Limaye VV, Ganvir PT (2015). Trypanosomiasis (Surra). Regional Disease Diagnostic Laboratory (Western Zone) Disease Investigation Section, Aundh, Pune-411007; Maharashtra, India.
  9. OIE Terrestrial Manual (2012). Trypanosoma evansi infection (Surra). Chapter 2.1.17. adopted by the World Assembly of Delegates of the OIE in May 2012.1-15.
  10. Pathak KM, Singh Y, van Meirvenne N, Kapoor M (1997). Evaluation of various diagnostic techniques for Trypansoma evansi infections in naturally infected camels. Vet. Parasitol. 69: 49-54. http://dx.doi.org/10.1016/S0304-4017(96)01091-6[CrossRef]
  11. Shah I, Ali US, Andankar P, Joshi RR (2011). Trypanosomiasis in an infant from India. J. Vector Borne Dis. 48: 122-123.
  12. Shegokar VR, Powar RM, Joshi PP, Bhargava A, Dani VS, Katti R, Zare VR, Khanande VD, Jannin J and Truc p (2006). Human trypanosomiasis caused by Trypanosoma evansi in a village in India: preliminary serologic survey of the local population. Am. J. Trop. Med. Hyg. 75(5): 869-70.
  13. Singla LD, Juyal PD, Sharma NS (2009). Immune responses to haemorrhagic septicaemia (HS) vaccination in Trypanosoma evansi infected buffalo-calves. Trop. Anim. Health Prod. 42: 589-595. http://dx.doi.org/10.1007/s11250-009-9461-1[CrossRef]
  14. Surra. The center for Food Security & Public Health, IOWA State University, College of Veterinary Medicine. Institute for International Cooperation in Animal Biologics. www.cfsph.iastate.edu [Last updated: September 2009].
  15. Trypanosoma evansi- Wikipedia, the free encyclopedia. http:// en.wiipedia.org/wiki/Trypanosoma evansi

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