Cellular and humoral immune responses to bivalent FMD vaccine were estimated in vaccinated cattle, buffaloes, sheep, goats and camels. Five animals of each species were vaccinated using a dose of I ml for sheep and goats and 2 ml for cattle, buffaloes and camels inoculated subcutaneously. It was found that both of the immune parameters were generally increased gradually to reach the highest value of cellular immunity by the 2e day, while that of neutralizing antibodies was reached by the  week to the 10th week post vaccination. It was noticed that vaccination of cattle and sheep resulted in higher and longer duration of immune response than those obtained in vaccinated goat and buffaloes. While in vaccinated camels there was no evidence of antibodies against FMD. On the other hand, there were no significant differences between the levels of cellular immunity in different vaccinated animal species.