Transdermal drug delivery seems to be overwhelming and alternative to other means of drug delivery via oral or intravenous. To treat the diabetes mellitus and to get rid of the traditional injection treatment which is a painful process and can cause infections and allergy, the drug delivery through the skin cells can substitute only if the skins cells permeability for the drug is increased, which is now done by chemical, ultrasonic and electrical methods. Drug delivery through the largest organ (skin) by dermal patches of psyllium based hydrogels was observed. In this article we have fabricated different psyllium based dermal patches of hydrogels for insulin delivery. Psyllium, a natural polysaccharide, is a dietary fiber and widely utilized in gel forming. To study the structural aspects of these various polymeric webs were categorized with FTIR, SEM and release related experiments such as swelling kinetics, swelling ratio and drug kinetics and the impact of pH on the release of insulin from medicated hydrogels has been concentrated to evaluate the medication discharge instrument in-vitro and in-vivo. Fickian diffusion mechanisms have been read for the release of insulin at diverse pH (5.4 and 7.5).