The present study describes the antioxidant and pancreatic lipase inhibitory properties of different hydroethanolic leaf extracts of Conocarpus lancifolius. Freeze drying assisted ultra-sonication was adopted for extract preparation. The results showed that highest total antioxidant power of 291 ± 0.50 mg ASE/g DE was exhibited by 60% ethanolic extract which was slightly lower than antioxidant power of BHA (309.16 ± 3.90 mg ASE/g DE). The β-carotene bleaching inhibition of 87.44 ± 1.20% was computed for 60% ethanolic leaf extract being statistically non-significant from BHA (89.41 ± 2.45%). The in-vitro anti-obesity attribute of extracts was assessed by measuring the inhibition of enzymatic activity of pancreatic lipase. The 60% ethanolic leaf extract exhibited maximum pancreatic lipase inhibition of 54.55 ± 0.72% but lower than standard drug orlistat (66.65 ± 0.68%). Findings explored the hidden antioxidant and pancreatic lipase inhibitory potential of Conocarpus lancifolius that may be exploited for naturopathic treatment of obesity and functional food development with anti-obesity attributes.