ResearchersLinks

Case Report · Volume 4, Issue 2, Pages 25–29, 29 April 2016 · Open Access

Primary Retrobulbar and Intraocular Malignant Melanoma in a Cat

· · ·

Article Info ⌄
Journal:
Research Journal for Veterinary Practitioners
Published:
29 April 2016

From the article

  • Primary Retrobulbar and Intraocular Malignant Melanoma in a Cat.
  • Intraocular melanoma in cats is infrequently described compared to canine melanocytic tumors.
  • In malignant diffuse iridial melanoma in cats, early enucleation while the tumor is still confined to the iris stroma seems to improve survival time.
  • Primary orbital melanoma without ocular involvement in a Balinese cat.

Selected from the article's own text.

Abstract

Jedsada Siripoonsub1, Katriya Chankow2, Sitthichok Lacharoje3, Anudep Rungsipipat1*

1Companion Animal Cancer Research Unit, Department of Pathology, Faculty of Veterinary Sciences; 2Small Animal Teaching Hospital, Faculty of Veterinary Sciences; 3Department of Pathology, Faculty of Veterinary Sciences, Chulalongkorn University, Bangkok-10330, Thailand. 

Abstract | Retrobulbar and intraocular melanoma in cats is infrequently described. The objective of this report is to describe the macroscopic, histopathological and immunohistochemical findings of intraocular and retrobulbar malignant melanoma in a cat. A 10-year-old, spayed female, domestic short hair cat presented a rapidly growing intraocular and retrobulbar mass affecting the right eye. The presence of this mass resulted in exopthalmos, blindness and multifocal hemorrhage. The cat died 4 weeks later and a complete necropsy was performed. The final diagnosis for this case was primary retrobulbar malignant melanoma with intraorbital involvement. Most of the feline intraocular tumors contained a tumor that are predisposed to trauma due to inflammation. Early enucleation is the treatment of choice for malignant melanocytic tumors and for blind or painful eyes. 

Keywords | Cat, Intraocular, Melanoma, Retrobulbar

ETHICALLY APPROVED

This article does not contain any studies with human participants or experimental animals performed by any of the authors.

ACKNOWLEDGEMENTS

This work was supported by Companion Animal Cancer Research Unit, Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok-10330, Thailand.

CONFLICT OF INTEREST

The authors declare that they have no financial or personal relationship(s) which may have conflicts of interest in writing this article.

AUTHOR’S CONTRIBUTION

All authors contributed equally in all details of this manuscript.

References

  1. Bourguet AE, Piccicuto V, Donzel, Carlus E, Chahory S (2015). A case of primary choroidal malignant melanoma in a cat. Vet. Ophthalmol. 18(4): 345–349. http://dx.doi.org/10.1111/vop.12233[CrossRef]
  2. Cagnini DQ, Salgado BS, Linardi JL, Grandi F, Rocha RM, Rocha NS, Teixeira CR, Piero FD, Sequeira JL (2012). Ocular melanoma and mammary mucinous carcinoma in an African lion. BMC Vet. Res. 8: 176. http://dx.doi.org/10.1186/1746-6148-8-176[CrossRef]
  3. Day MJ, Lucke VM (1995). Melanocytic neoplasm in the cat. J. Small Anim. Pract. 36: 207–213. http://dx.doi.org/10.1111/j.1748-5827.1995.tb02898.x[CrossRef]
  4. Dees DD, Mac Laren NE, Teixeira L, Dubielzig RR (2013). An unusual case of ocular melanosis and limbal melanocytoma with benign intraorbital extension in a dog. Vet. Ophthalmol. 16(Suppl 1): 117–122. http://dx.doi.org/10.1111/vop.12009[CrossRef]
  5. De Lorimier LP (2006). Primary orbital melanoma without ocular involvement in a Balinese cat. Can. Vet. J. 47: 225–228.
  6. Grahn BH, Peiffer RL, Cullen CL, Haines DM (2006). Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling. Vet. Ophthalmol. 9(6): 395–403. http://dx.doi.org/10.1111/j.1463-5224.2006.00479.x[CrossRef]
  7. Gunduz K, Shields JA, Shields CL, Eagle RC (1998). Choroidal melanoma in a 14-year-old patient with ocular melanocytosis. Arch. Ophthalmol. 116: 1112–1114. http://dx.doi.org/10.1001/archopht.116.8.1112[CrossRef]
  8. Kalishman JB, Chappell R, Flood LA, Dubielzig RR (1998). A matched observational study of survival in cats with enucleation due to diffuse iris melanoma. Vet. Ophthalmol. 1: 25–29. http://dx.doi.org/10.1046/j.1463-5224.1998.00006.x[CrossRef]
  9. Luna LD, Higginbotham ML, Henry CJ, Turnquist SE, Moore AS, Graham JC (2000). Feline non-ocular melanoma: a retrospective study of 23 cases (1991-1999). J. Feline Med. Surg. 1: 173–181. http://dx.doi.org/10.1053/jfms.2000.0092[CrossRef]
  10. Paridaens AD, Minassian ADC, McCartney ACE, Hungerford JL (1994). Prognostic factors in primary malignant melanoma of the conjunctiva: a clinicopathological study of 256 cases. Brt. J. Ophthalmol. 78: 252–259. http://dx.doi.org/10.1136/bjo.78.4.252[CrossRef]
  11. Patnaik AK, Mooney S (1988). Feline melanoma: A comparative study of ocular, oral and dermal neoplasms. Vet. Pathol. 25: 105–112. http://dx.doi.org/10.1177/030098588802500201[CrossRef]
  12. Payen G, Estrada M, Clerc B, Chahory S (2008). A case of conjunctival melanoma in a cat. Vet. Ophthalmol. 11(6): 401–405. http://dx.doi.org/10.1111/j.1463-5224.2008.00657.x[CrossRef]
  13. Ramos-Vara JA, Miller MA, Johnson GC, Turnquist SE, Kreeger JM, Watson GL (2002). Melan A and S100 protein immunohistochemistry in feline melanomas: 48 cases. Vet. Pathol. 39: 127–132. http://dx.doi.org/10.1354/vp.39-1-127[CrossRef]
  14. Schobert CS, Labelle P, Dubielzig RR (2010). Feline conjunctival melanoma: histopathological characteristics and clinical outcomes. Vet. Ophthalmol. 13(1): 43–46. http://dx.doi.org/10.1111/j.1463-5224.2009.00758.x[CrossRef]
  15. Semin MO, Serra F, Mahe V, Deviers A, Regnier A, Raymond-Letron I (2011). Choroidal melanocytoma in a cat. Vet. Ophthalmol. 14(3): 205–208. http://dx.doi.org/10.1111/j.1463-5224.2010.00860.x[CrossRef]

Services

Article usage statistics

Loading…

Primary Retrobulbar and Intraocular Malignant Melanoma in a Cat · ResearchersLinks