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Short Communication · Volume 1, Issue 1, Pages 1–3, 11 December 2013 · Open Access

Comparative Efficacy of Two Dose Levels of Albendazole against Naturally Acquired Nematode Infections in Goats

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Journal:
The Journal of Advances in Parasitology
Published:
11 December 2013
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From the article

  • Comparative efficacy of two dose levels of albendazole against naturally acquired nematode infections in goats.
  • This study was designed to ascertain the therapeutic level of Anthelmintics in goats owing to the fact that these are metabolized rapidly in goats than that of sheep and in turn require a higher dose for effective parasite–control.
  • A total of 30 naturally infected goats, with natural gastrointestinal nematode infestation, were selected for therapeutic trial.
  • Animals in group A were treated with a dose rate of 1 ml/20 Kg body weight (recommended dose), group B was treated with 1.25 ml/20 Kg body weight, whereas animals in group C served as negative control.

Selected from the article's own text.

Abstract

Habibun Nabi1*, Khalid Saeed1, Muhammad Lateef1, Aneela Zameer Durrani2, Muhammad Haroon Akbar1, Muhammad Imran Rashid1
1Department of Parasitology, University of Veterinary and Animal Sciences, Lahore, Pakistan; 2Department of Clinical Medicine & Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan.
*Corresponding author: habibunnabi30@gmail.com

ABSTRACT
The small ruminants are threatened by a number of health hazards around the globe, however, gastrointestinal nematodes are considered most dangerous. These infections are controlled mainly by variety of chemotherapeutic agents. This study was designed to ascertain the therapeutic level of Anthelmintics in goats owing to the fact that these are metabolized rapidly in goats than that of sheep and in turn require a higher dose for effective parasite–control. A total of 30 naturally infected goats, with natural gastrointestinal nematode infestation, were selected for therapeutic trial. These animals were randomly divided into three equal groups and were called Group A, B and C and were treated with different level of Albendazole (Albasym®). Animals in group A were treated with a dose rate of 1 ml/20 Kg body weight (recommended dose), group B was treated with 1.25 ml/20 Kg body weight, whereas animals in group C served as negative control. Percent reduction in eggs per gram of faeces (EPG) was calculated on day 0, 7th, 14th and 28th post medication. Non–significant difference (P>0.05) in egg reduction at recommended dose and at higher dose was observed while significant (P<0.05) reduction in egg shedding as compared with control group was recorded. The EPG reduction at day 7 post medications at recommended dose and higher dose was 98.81% and 100%, respectively while reduction at day 14 post medication was 95% and 99.93%, respectively. Data shows that higher dose of Albendazole resulted in 93% reduction in EPG while 81% reduction was recorded at recommended dose level at 28th day post medication. Taken together higher dose is more effective than recommended dose in the control of goat nematodes, however, it required to be investigated the long–term effects on the resistance development and continuity to such therapeutic effects in future.

Key Words: Nematode infections, Goats, Albendazole, Dose–levels, Chemotherapy

Short Communication

The Journal of Advances in Parasitology1 (1): 1 – 3

Comparative Efficacy of Two Dose Levels of Albendazole against Naturally Acquired Nematode Infections in Goats

Habibun Nabi1*, Khalid Saeed1, Muhammad Lateef1, Aneela Zameer Durrani2, Muhammad Haroon Akbar1, Muhammad Imran Rashid1

1Department of Parasitology, University of Veterinary and Animal Sciences, Lahore, Pakistan;
2Department of Clinical Medicine & Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan;

*Corresponding author: habibunnabi30@gmail.com

ARTICLE CITATION: Nabi H, Saeed K, Lateef M, Durrani AZ, Akbar MH and Rashid MI(2014). Comparative efficacy of two dose levels of albendazole against naturally acquired nematode infections in goats. J. Adv. Parasitol. 1 (1): 1 – 3.
Received: 2013–07–17, Revised: 2013–12–03, Accepted: 2013–12–05
The electronic version of this article is the complete one and can be found online at ( http://dx.doi.org/10.14737/journal.jap/2014/1.1.1.3 ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

ACKNOWLEDGEMENT

This study was carried out in Veterinary Research and Disease Investigation Center Balogram District Swat, Khyber Pakhtunkhwa, Pakistan as a part of MPhil research. We are very thankful to the staff for their support and help.

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