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Targeting Cellular and Virus Encoded LncRNAs: Emerging Opportunities for Novel Anti-influenza Therapies

Targeting Cellular and Virus Encoded LncRNAs: Emerging Opportunities for Novel Anti-influenza Therapies

 Shubhada K Chothe, Bhushan M Jayarao and Suresh V Kuchipudi

 Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.

Email | skuchipudi@psu.edu

ABSTRACT

 Long non coding RNAs (lncRNA) contribute to a large proportion of the cellular RNA and are involved in regulating a plethora of biological and pathological processes. There is a strong evidence to suggest the association of differential regulation of non-coding RNAs (ncRNAs) to a number of disease processes including viral infections. Cellular and virus encoded lncRNAs are emerging as novel regulatory factors which can escape the anti-protein environment in the virus infected cells and are likely to be conserved across the species. Here, we summarize our current knowledge about the role of lncRNAs in influenza virus infection and the exciting prospect of exploiting lncRNAs as targets to develop novel anti-viral therapies.

 

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Hosts and Viruses

June

Vol.6, Iss.3, Pages 42-84

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