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Sub Chronic Toxic Effects of Ethanolic Pongamia pinnata and Eucalyptus camaldulensis Leaf Extracts on Hematological and Biochemical Parameters of Blood in the Male Albino Mice

Sub Chronic Toxic Effects of Ethanolic Pongamia pinnata and Eucalyptus camaldulensis Leaf Extracts on Hematological and Biochemical Parameters of Blood in the Male Albino Mice

Shahid Iqbal1,2, Zulha Javed1, Mushtaq Hussain Zahid3, Qurat ul Ane Gillani4 and Furhan Iqbal1,*

1Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan
2Department of Zoology, Government Emerson College, Multan
3Department of Biological Sciences, Gomal University, Dera Ismail Khan
4Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore
 
Shahid Iqbal and Zulha Javed have contributed equally to the manuscript.
 
* Corresponding author: furhan.iqbal@bzu.edu.pk

ABSTRACT

This study involves effects of ethanolic extracts of leaves of Pongamia pinnata (L.) Pierre and Eucalyptus camaldulensis Dehnh on hematological parameters and biochemical components of blood serum of male albino mice. The extracts were administrated orally (100 mg/ ml solvent/ Kg body weight) for 15 days and it was observed that the complete blood count (CBC) remained unaffected while cholesterol (P = 0.03) and triglyceride (P = 0.008) levels in serum were significantly elevated in P. pinnata leaf extract treated mice. Mice treated with E. camaldulensis leaf extract had significantly reduced white blood cells (P = 0.05), platelets (P = 0.05), alanine aminotransferase (P = 0.04) and significantly increased mean corpuscular hemoglobin levels (P = 0.04) as compared to control group. Our results indicated that both leaf extracts had tendency to disturb the blood biochemistry of healthy male albino mice. The effects were more pronounced in mice orally treated with E. camaldulensis leaf extract for 15 days.

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Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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