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Immunogenic Proteins of Capripox Virus: Potential Applications in Diagnostic/Prophylactic Developments

Immunogenic Proteins of Capripox Virus: Potential Applications in Diagnostic/Prophylactic Developments

Anand Kushwaha, Amit Kumar, Aparna Madhavan, Durga Goswami, Golmei Poulinlu and Gnanavel Venkatesan* 

Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar 263138, Nainital District, Uttarakhand, India.

gnanamvirol@gmail.com 

ABSTRACT

Capripoxvirus (CaPV) infections are highly contagious and OIE notifiable viral diseases of sheep, goats and cattle. They are endemic in most parts of the globe associated with significant production losses due to high morbidity, high mortality rate and animal trade restrictions. Though several diagnostics including molecular tools are available, recombinant protein based diagnostic assays namely ELISA is safer and robust to handle large sample size and also to minimize labor/time. However, the genus Capripoxvirus encodes putative 147 proteins in their genome, among which some of them are reported as potential immunogenic candidate genes. Selection and use of such candidate immunogenic proteins from an array of genes located at different structures of a mature virion are the real challenge and time consuming task for researchers. Nevertheless, identification of candidate gene(s) using advanced bioinformatic tools will ease the process and can select the suitable protein(s) to use in the development of specific and sensitive diagnostic assays and also effective vaccine candidates which are vital elements in control and eradication of any infectious disease from an endemic country. In this review, we describe different structures of mature pox virion with reference to vaccinia virus (VACV), list of immunogenic candidate genes presents in CaPV genome and their potential use in diagnostic/vaccine developments. 

 

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Hosts and Viruses

December

Vol. 6, Iss. 6, Pages 130-146

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