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Genetic Association of LCT-13910C/T and LCT-22018G/A with Adult Type Hypolactesia in Pakistan

Genetic Association of LCT-13910C/T and LCT-22018G/A with Adult Type Hypolactesia in Pakistan

Hafiz Suboor ul Hassan and Saira Malik*

Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, 54590, Pakistan. 

*  Corresponding author: saira.mmg@pu.edu.pk

 

ABSTRACT

Adult type hypolactesia commonly known as lactose intolerance usually occur in adulthood when expression of the lactase gene diminishes. Two SNP’s LCT-13910C/T and LCT-22018G/A are considered to be associated with the development of lactose intolerance in humans. The aim of the study was to evaluate the role of LCT-13910C/T and LCT-22018G/A with the development of lactose intolerance in Pakistani population. A total of 160 samples were collected and tetra primer ARMS-PCR was used for genotyping. 79.48% lactose intolerant individuals showed homozygous LCT-13910CC genotype and 16.66% showed heterozygous CT genotype. For LCT-22018G/A, 43.75% lactose intolerant individuals showed homozygous GG genotype, while 43.58% patients showed heterozygous GA genotype. Thus, different variants of genotype -13910T/C and -22018G/A of the individuals were found to be associated with the development of lactose intolerance in patients of the studied population. Milk intake status and gastrointestinal disease are among the other factors that may influence the onset of lactose intolerance in patients and controls. 
 

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Pakistan Journal of Zoology

October

Vol. 51, Iss. 5, Pages 1599-1997

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