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Biogenic Copper Nanoparticles as a Nanoscale Solution to Address Multiple Drug Resistance in Bacteria

Biogenic Copper Nanoparticles as a Nanoscale Solution to Address Multiple Drug Resistance in Bacteria

Ayesha Talib1,2, Khanzadi Nazneen Manzoor1, Wajahat Ali1, Maria Saeed1, Muhammad Asif Gondal1, Malik Badshah3 and Abid Ali Khan1*

1Department of Biosciences, COMSATS University Islamabad, Park Road Tarlai Kalan, 45550 Islamabad, Pakistan 
2Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
3Department of Microbiology, Quaid i Azam University, Islamabad, Pakistan
 
Ayesha Talib and Khanzadi Nazneen Manzoor contributed equally to this article.

*      Corresponding author: abidalikhan@comsats.edu.pk

Fig. 1.

UV Vis. spectroscopy demonstrating the absorption peak at 330 nm. Copper salt solution was used as control.

Fig. 2.

SEM image of Cu nanoparticles. The nanoparticles appear as (grey coloured) sphereical nanoparticles and the purified concentrated sample still show no signs of aggregation.

Fig. 3.

FTIR spectrum obtained for the biogenic CuNPs.

Fig. 4.

Antimicrobial susceptibility testing of strains by disc diffusion assay showed no zones of inhibitions (except for E. coli against two drugs): a-b) K. Pneumoniae; c-d) A. baumannii; e-f) MRSA; g-h) VRSA; and i-j) E. coli.

Fig. 5.

Antimicrobial susceptibility testing of strains by disc diffusion method. a-b) K. Pneumoniae; c-d) A. baumannii; e-f) MRSA; g-h) VRSA; and i-j) E. coli.

Fig. 6.

Minimum inhibitory concentration (MIC) (in mM) of CuNPs against the selected MDR bacterial isolates.

Fig. 7.

Bactericidal activity of copper nanoparticles at different concentration of 30 μL, 40 μL and 50 μL.

Pakistan Journal of Zoology

February

Vol. 53, Iss. 1, Pages 1-400

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