Assessment of Hepatitis E Viral Infection and its Effect on Egyptian Pregnant Mothers
Assessment of Hepatitis E Viral Infection and its Effect on Egyptian Pregnant Mothers
A. A- E. Abo-Elkhier1, K. S. E. Abdel-Wahab2, M. A. Ali3, M. A-H. El-Sayed4, N.A-K. Saleh5 and A. A. Atef6
ABSTRACT
The current study was performed to determine the prevalence of HEV in Egyptian pregnant women. and to estimate the risk or prenatal transmission of the virus and its effect in infected pregnant women. 120 aborted women between 17-36 years old and 120 women aged matched who had normal full-term pregnancy in labor were included in the present study. Maternal blood was tested for anti-HEV IgG and IgM antibody and the positive cases were tested for HEV Ag and HEV RNA. The fetal tissue from anti-HEV IgG and IgM positive aborted women and cord serum of infant of anti-HEV IgG and IgM positive full term delivered women were tested for REV Ag and HEV RNA. Among 120 aborted women. 2.5 (3/120) of them were positive result with anti-HEV IgM. Anti-HEV IgG, HEV RNA and HEV Ag. also 11.7 % (14/120) of them gave positive result with anti-HEV IgG. HEV RNA and HEV Ag. and 5.8 % (7/120) or them were positive for anti-HEV IgG only. Also 13 of 120 (10.83 %) full term delivered women were anti-HEV IgG positive only. All results or liver function tests of HEV-RNA positive aborted women appeared to be slightly higher than or HEV RNA negative aborted women. These differences was statistically significant (P 0.05) (Except total protein and alkaline phosphatase). It was found that 3 anti-HEV IgM. anti-HEV IgG. HEV RNA and HEV Ag positive pregnant women transmitted the virus to their all fetus (100%). While 14 anti-HEV IgG, HEV RNA and HEV Ag positive pregnant women transmitted the virus to 12 (85.7 %) of their fetus and the fetus died and terminated to abortion. However, the 7 anti-HEV IgG positive aborted women did not transmit the infection to their fetus. Also, the cord serum of infant of 13 anti-HEV IgG positive term delivered women gave negative result with HEV-RNA. HEV RNA infected pregnant women transmitted the virus to their fetus and the fetus died and terminated to abortion.
To share on other social networks, click on any share button. What are these?
