Tanveer Ahmad1, Tariq Mehmood1, Muhammad Shahid1, Adnan Ahmad1,2, Muhammad Asim Raza Basra1, Muhammad Zia-ur-Rehman3* and Munawar Ali Munawar1
...e problem. In this work, sulfonamides and sulfonylurea-sulfonamide hybrids were synthesized from simple molecule of 4-aminobenzenesulfonamide by its reaction with aryl sulfonyl chlorides. Anti-diabetic activities of these pharmacophores were studied by oral glucose tolerance test (OGTT) percentage analysis on Sprague Dawley (SD) rats at the dose of 20mg/kg using glibenclamide (GC). Among t...
Dilan Ozmen Ozgun1, Gonca Alak2, Arzu Ucar2, Sinan Bilginer3, Halise Inci Gul3, Mahmut Kocaman2, Cem Yamalı3, Veysel Parlak2, Muhammed Atamanalp2, Ahmad Maslat4 and Telat Yanık2*
...p-hydrazinobenzenesulfonamide hydrochloride in 1:1.1 mol ratio in ethanol (25 ml) in the presence of glacial acetic acid (0.05 ml) was refluxed for synthesis of 4-(3-(4-Bromophenyl)-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide, B4, for 7h at first experiment. Effects of B4 on antioxidant enzymes of gill and liver, and changes in hematological parameters were determined in rainb...
Hafiz Adnan Ahmad1,2*, Muhammad Aslam2, Salman Gul2, Tariq Mehmood2 and Munawar Ali Munawar2
...ries of 1,2,5-oxadiazole-sulfonamide hybrids (4a-4j) in search of more potent anti-inflammatory agents. Title compounds were synthesized by chlorosulfonation of 3,4-diphenyl-1,2,5-oxadiazole (3) followed by condensation with amines and all derivatives were obtained in moderate to good yield. All synthesized hybrids were characterized with spectroscopic techniques and further evaluated for anti-inflammatory potential. The synthesized hybrids were screened in vi...
Sofiane Tamendjari1,2*, Farida Bouzebda Afri1,2, Lina Chaib1, Hebib Aggad3, Zoubir Bouzebda1,2
...ce to penicillin (100%), sulfonamides (93.10%) and multiple resistances were reported in this study. Staphylococci, coagulase-positive Staphylococci and in particular S. aureus are hygiene indicators that should not be neglected. For this reason, the general provisions of the slaughterhouse must be respected, the hygiene conditions improved and the professionals of the sector trained for good production and manufacturing practices. In addition, the use of anti...
