Issue · 2016
Vol.3, Iss. 1
5 articles · All issues →
ReviewRecent Advances in Aptamer Based Biosensors for Detection of Antibiotic Residues
Atul Sharma, Aruna Chandra Singh, Gautam Bacher, Sunil Bhand
Antibiotics are widely used as bacteriostatic or bactericidal agents either to kill or inhibit the growth of microorganisms. Their abuse results in various side effects on the human health, environment and agriculture. The occurrence of bacterial “suprai…
22 Nov 2016
Research ArticleEvaluation of the Ability of Anti-Lipopolysaccharide Aptamers to Discriminate Various Pathogenic E. coli Bacteria
John G. Bruno
Lengthy 200 base DNA aptamers were developed against extracted lipopolysaccharides (LPS) of E. coli O157 and the so called “Big six” non-O157 Shiga-toxin producing E. coli (STEC) serovars (O26, O45, O103, O111, O121 and O145). These aptamers were a…
23 Jan 2017
ReviewFeasibility of Anti-Idiotypic Aptamers to Detect Rickettsia Exposure
John G. Bruno
Twenty-seven DNA aptamers were developed against the Fab fragments of murine antibodies developed to bind Rickettsia rickettsii and Rickettsia typhi. A feasibility study was conducted to generate anti-idiotypic aptamers against Fab fragments of these antibodie…
5 Jun 2017
ReviewThe Point behind Translation of Aptamers for Point of Care Diagnostics
Tarun Kumar Sharma, John G. Bruno, William C. Cho
Owing to the high affinity and specificity in recent years aptamers, have emerged as competitive tools with the potential to replace antibodies in many diagnostic formats. The aptamer industry is continuously growing to create space in research and diagnostics…
22 Oct 2016
Research ArticleEvaluation of Novel Anti-VEGF Molecules in the Animal Model of Human Lung Cancer
Sanjukta Chakrabarti, Colin J. Barrow, Rupinder K. Kanwar, Venkata Ramana, Rakesh N. Veedu, Jagat R. Kanwar
Abnormal angiogenesis or the formation of aberrant vasculature in humans, may lead to various pathological conditions including tumor development. The most important factor implicated in the angiogenic processes is vascular endothelial growth factor (VEGF) pro…
4 Nov 2017