Copper Oxide Nanoparticles: Synthesis, Characterization, and Their Biological Effects on Microbial and Cancer Cells
Copper Oxide Nanoparticles: Synthesis, Characterization, and Their Biological Effects on Microbial and Cancer Cells
Mosleh Mohammad Abomughaid
UV Visible spectroscopy of synthesized CuONPs.
FT-IR spectrum representing the functional groups of synthesized CuONPs.
(A) AFM analysis of three-dimensional image showing the topology and distribution characteristics of synthesized CuO NPs. (B) FE-SEM analysis of CuO NPs.
Antibacterial activity CuONPs against Gram-negative bacteria (A); Gram-positive bacteria (B) and antifungal activity (C) of CuONPs. * p < 0.05 compared to control.
(A) Effect of CuONPs on A549 cell viability (%) using MTT assay. (B) Phase contrast microscopic image of the A549 cells treated with different concentrations of CuO NP. (a) Control, (b) 1 μg/mL, (c) 10 μg/mL, (d) 50 μg/mL, (e) 100 μg/mL, (f) 300 μg/mL, (g) 500 μg/mL. * p < 0.05 compared to control.
Effect of CuONPs on ROS generation in A549 lung cancer cells. * p < 0.05 compared to control.
Annexin V/PI apoptosis staining assay for detecting apoptotic bodies formation in A549 cells. (A) Control, (B) 44.33 μg/ml CuO NP.
