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Case Report · Volume 8, Issue 2, Pages 147–150, 1 February 2020 · Open Access

Pleomorphic Variant of Leydig Cell Tumor in a Dog

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Journal:
Advances in Animal and Veterinary Sciences
Published:
1 February 2020
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  • Neoplastic cells showed marked cellular and nuclear pleomorphisms, which is one of criteria for malignant Leydig cell tumor.
  • By contrast, herein we report untypical, benign Leydig cell tumor with significant cellular polymorphism.
  • Immunohistochemistry was performed to differentiate the Leydig cell tumor from other testicular tumors.
  • Immunohistochemical analysis revealed that neoplastic cells showed homogenous positivity for vimentin, c-kit (CD117), and Melan A, confirming that neoplastic cells were derived from Leydig cells (Figure 4).

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Abstract

Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha Young Lim, Jung Hyang Sur*

Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, Korea.

Abstract | Leydig cell tumor is relatively common in dogs, accounting for approximately a quarter to half of all canine testicular tumors. While most Leydig cell tumors are benign, malignant forms have been reported. A 13-year-old Pomeranian visited a local hospital with a chief complaint of edema in the left testicle. Radiography and ultrasonography revealed a mass in the left testicle; therefore, orchidectomy was performed. Microscopic analyses revealed the growth of a neoplastic mass compressing adjacent seminiferous tubules. Immunohistochemistry confirmed that the neoplasm was derived from Leydig cells. Neoplastic cells showed marked cellular and nuclear pleomorphisms, which is one of criteria for malignant Leydig cell tumor. However, the immediate postsurgical outcome was good, and seven months after surgery, the patient recovered well without any complications or recurrence. Therefore, the present study indicates that cellular and nuclear polymorphisms cannot be alone inform the differentiation between benign and malignant Leydig cell tumor in dogs.

Keywords | Dog, Leydig cell tumor, Testicular tumor, Diagnostic pathology, Histopathology 

Acknowledgements

The authors thank Mr. Y-S. Yoon (Shine veterinary clinics) for providing clinical data and tissue samples. This work was supported by the Bio and Medical Technology Development Program of the NRF funded by the Korean government, MSIT [grant number 2016M3A9B6903437].

Authors Contribution

SHK collected clinical data, drafted and revised the manuscript. BJS, SHC, HYL interpreted the clinical and histopathological data. JHS designed the project and critically revised the manuscript.

Conflict of interest

The Authors declare that there is no conflict of interest.

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Pleomorphic Variant of Leydig Cell Tumor in a Dog · ResearchersLinks