Disposal of sewage sludge is a critical issue worldwide for the environmentalists. There are many methods for its disposal. The most suitable and economical method is its land application. Lagenaria siceraria L. plant was grown in various amendments of soil and sewage sludge to check the tolerance of the plant and to select the optimized mixing of sewage sludge with soil for this particular plant. Estimation of biochemical parameters like chlorophyll content, carotenoid content, and protein content along with total biomass of the plant showed that the soil mixed with 20% sewage sludge showed maximum growth of the plant. Meanwhile, antioxidants like TPC, Ascorbic acid content and antioxidant potential (DPPH, ABTS, FRAP) were also measured and maximum values were found in 20% to 40% of sewage sludge. Hence, sewage sludge may be exploited for the useful purposes in a controlled manner.