The effects of Lead nitrate on liver, gizzard, and kidney of Herring gull (Larus argentatus) were studied. Significant changes were observed after high and low concentrations of Lead nitrate were injected to Larus argentatus. Paraffin sections showed major alterations at high and low concentration of Lead nitrate in liver, gizzard and kidney. High concentration of Lead nitrate induced, severe dystrophy along with hepatic necrosis; reduction in thickness of muscular layer of gizzard and marked alterations in loop of Henle of kidney. While, low concentration of Lead nitrate showed slight alteration in loop of Henle in kidney; disruption and thinning of epithelium of gizzard and mild disruption of hepatic cords in liver. No laceration was observed in the mentioned body tissues of Larus argentatus of control group.