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Mini-Review · Volume 3, Issue 5, 19 January 2017 · Open Access

Avian coronavirus Main Replicase Enzymes at a Glance

Affiliations & Notes ⌄
  1. 1Applied Molecular Biology and Serology Laboratory, Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine, University of São Paulo, Brazil. giselleayres@gmail.com
Article Info ⌄
Journal:
Hosts and Viruses
Published:
19 January 2017
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From the article

  • The first 5’ two thirds of this genome, correspondent to a wide ORF1 (also called replicase gene), code for non-structural proteins (nsps) that are enrolled in viral transcription, replication and pathogenesis.
  • Nsps act in a complex replication process, made possible by the special characteristics of AvCoV genome.
  • The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication.
  • Changes in non-structural protein 3 are associated with attenuation in avian coronavirus infectious bronchitis virus.

Selected from the article's own text.

Abstract

Avian Coronavirus (AvCoV) belongs to the Gammacoronavirus genus from the Coronaviridae family and Nidovirales order. Coronaviruses have a single-stranded positive RNA genome, corresponding to the largest known RNA genome, with about 27kb for AvCoV. The first 5’ two thirds of this genome, correspondent to a wide ORF1 (also called replicase gene), code for non-structural proteins (nsps) that are enrolled in viral transcription, replication and pathogenesis. The last 3’ one-third of the genome codes the four structural and accessory proteins. Nsps act in a complex replication process, made possible by the special characteristics of AvCoV genome. This manuscript aims to present an overview of the main aspects of the current knowledge on the main AvCoV replicase genes.

Acknowledgments

The authors are grateful to FAPESP (grant numbers 2011/00874-5 and 2011/00603-1) and CNPq (grant number 301225/2013-3 ) for the financial support.

Conflict of Interest

There is no conflict of interest.

Authors’ Contribution

Both authors contributed equally to this paper.

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Avian coronavirus Main Replicase Enzymes at a Glance · ResearchersLinks