Intravenous Administration of Arecoline Induces Biphasic Modulations in Blood Pressure in Anaesthetized Rats
Meiping Deng1, Xiaowen Ye1, Jiashan Wu1, Lijuan Chen1, Xiaoxia Jiang1, Changzheng Zhang1, Peiling Zhou1* and Yi Luo2*
The molecular formula of arecoline.
Representative recordings of blood pressure (BP) changes after intravenous injections of arecoline. (A) saline; (B-D) 0.06, 0.2 and 0.6 mg/kg arecoline, respectively, in which the BP exhibited biphasic regulations: an initial downregulation followed by a subsequent upregulation. Arrow: time of injection. iv: intravenous injection.
The reaction time for BP changes after intravenous injection of arecoline. (A) The latency of BP changes; (B) the duration of BP downregulation in Period 1; (C) the duration of BP upregulation in Period 2. The circles denote raw data; numbers presented in parentheses denote the number of measurements. **P < 0.01.
Mean arterial pressure (MAP) changes after intravenous injection of arecoline. No significant differences were observed among groups (0.06, 0.2 and 0.6 mg/kg of arecoline) in the pre-test, but a remarkable decrease was observed in Period 1 followed by a marked increase in Period 2, after intravenous arecoline treatments. *P < 0.05; **P < 0.01.
The maximum changes in MAP after intravenous injection of arecoline. (A) Dose-dependent increases in MDMAP; (B) dose-dependent increases in MIMAP. MDMAP: maximum decreased MAP; MIMAP: maximum increased MAP. **P < 0.01.
The area under curve (AUC, MAP change relative to the reaction time) after intravenous injections of arecoline. (A) Representative AUCs of different treatment groups (0.06, 0.2 and 0.6 mg/kg of arecoline). (B) Histograms of the AUCs among groups; B1, the total AUC; B2, AUC in Period 1; B3, AUC in Period 2. *P < 0.05; **P < 0.01.