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Effect of Fungicide Toxicity on Apoptosis, DNA Damage, and Antioxidant Enzymes in Van Fish

Effect of Fungicide Toxicity on Apoptosis, DNA Damage, and Antioxidant Enzymes in Van Fish

Aslı Çilingir Yeltekin

Department of Chemistry, Faculty of Science, University of Van Yuzuncu Yil, 65080, Turkey

 
* Corresponding author: aslicyeltekin@gmail.com, aslicilingir@yyu.edu.tr

ABSTRACT

The extensive use of tebuconazole, an azole group fungicide, causes undesirable toxicity in non-targeted organisms, including fish in aquatic environments. We investigated metabolic responses by observing apoptosis (caspase- 3), DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), malondialdehyde (MDA), and antioxidants (SOD, CAT, GSH-Px) activity in Van fish kidney and muscle tissue after 24., 48., 72., and 96. h of tebuconazole exposure at a concentration of 2.5 mg/L. The obtained results indicated that caspase-3, 8-OHdG, and MDA levels significantly increased compared to the control (p < 0.05). The kidney and muscle tissues indicated a significant decrease in antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)) compared to the control (p< 0.05). Therefore, these data may reflect one of the molecular pathways that play a role in tebuconazole toxicity.

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Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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