ResearchersLinks

← All books

Book

Fundamental Immunological Concepts

Faisal Rasheed Anjum, Sidra Anam, Sajjad ur Rahman, Muhammad Imran Arshad

About this book

Given the fact that pathogens and hosts are in continuous arm race for survivability, it is primarily the host immune system that determines the ultimate fate. Predominantly, it functions to prevent and contain multiple pathogens, both of intra- or extra-cellular nature, and eliminate them. Immune system is not vital for physiological function of the systems; however, the photobiotic environment is required to be achieved for survivability. It is this acknowledgement of the immune system centrality that is proudly dealt and published in this textbook, Fundamentals Immunological Concepts, forging a greater level of granularity in basic molecular and cellular components of the immune responses and to lay foundations to prevention of infectious disease.

The book project kick-start the literature elegantly from fundamental concepts to advances approaches in immune responses – providing a complete guide for fresh and fully annotated survey of the literature. While teaching immunology is counterfeiting, it proposes an astonishing area of biology. To bring true flavour and joy for new students of immunology, the book offers assembly of outstanding and experienced team members with up-to-date information on this rapidly evolving area of research. The book also offers versatility in presentation, elegance in connectivity and fluency in writing – all standard benchmarks of critical thinking and pedagogies are met. These quality features are exceptional to Fundamentals Immunological Concepts and thus overweight on pre-existing books of this kind.

 

About the Authors
 
Faisal Rasheed Anjum
DVM, M.Phil Microbiology, PhD scholar (Microbiology) Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan
 
Sidra Anam
BSc (Hons), M. Phil Microbiology, PhD scholar (Microbiology) Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan
 
Sajjad ur Rahman
DVM, MSc (Hons) Veterinary Microbiology, PhD Microbiology, Postdoc (USA) Director/Professor, Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan
 
Muhammad Imran Arshad
DVM, MSc (Hons) Veterinary Microbiology, M.Phil. Infection & Immunity, PhD (France) Postdoc (USA)
Assistant Professor, Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan 

Table of contents

 
Table of Contents
 
Chapter 1: Introduction to Immune System
Time Line History of Immunology Branches of Immunology Immunity
Need for Self/Nonself recognition Pros and Cons of Immune system Summary
References
Useful links
 
Chapter 2: Structural Components of Immune System Hematopoiesis
Classification of blood cells
Lymphoid organs
Summary
References
Useful Links
 
Chapter 3: Antigens and Antibodies
Antigens
Antibody
Types of Immunoglobulins
Generation of monoclonal antibodies
Summary
References
Useful links
 
Chapter 4: Immune Receptors
Immune Receptors
Pattern recognition receptors (PRRs)
Killer activation receptors (KARs)
Killer inhibition receptors (KIRs)
Fc receptors
Complement receptors (CRs)
B and T cell receptors
Summary
References
Useful links
 
Chapter 5: Cytokines and Cytokine Receptor Mediated Signalling Cytokines
Classification of cytokines
Cytokine Antagonism
Cytokines and Diseases
Cytokine Based Therapies
Summary
References
Useful links
 
Chapter 6: Innate Immune Responses
First Line of defense
Second line of defense
Summary
References
Useful links
 
Chapter 7: Antigen Presentation and Processing
Discovery of MHC molecule
General Structure of MHC Molecules
The antigen Processing Pathways
Cross Presentation of Antigens
Presentation of Non-peptide Antigens
Summary
References
Useful links
 
Chapter 8: Development of B Lymphocytes
Hematopoiesis during gestation
Developmental stages of B lymphocytes
Development of B1 and marginal B cells
Pathological conditions related to B cells
Summary
References
Useful links
 
Chapter 9: Activation and Effector Functioning of B Lymphocytes
T Dependent Responses
T Independent Reponses (TIR)
Effector functions mediated by antibodies
Features of Ig isotypes
Negative regulation of B cells
Summary
References
Useful links
 
Chapter 10: Development of T Lymphocytes
Thymocyte development inside thymus
Development of Thymocyte Receptors
Thymic Selection of Thymocytes
DP Thymocyte commitment to single positive (CD4 or CD8) T cells
Final maturation of thymocytes
Development of self-tolerance due to T cells
Summary
References
Useful links
 
Chapter 11: T Cell Activation and Effector Functions
Activation of T lymphocytes
Differentiation of T cells
TH1/TH2 and TH17/TREG Paradigm
T cell recognition of Antigens and their effector functions
Summary
References
Useful links
 
Chapter 12: Tumor Immunology 
Malignant transformation
Genetic basis for tumor development
Host immune response to cancer
Mechanisms promoting the tumor growth
Cancer therapies
Evasion of tumor cells from the host immune system
Summary
References
Useful links
 
Chapter 13: Immune Disorders
Primary immune disorders
Secondary Immune Disorders
Hypersensitivity Reactions
Autoimmune disorders
Summary
References
Useful links
 
Chapter 14: Vaccine Immunology
History of vaccination
Vaccination Vs Immunization
Types of vaccines
Adjuvants & Preservatives in Vaccines
Vaccine Delivery Systems
Vaccine administration Routes
Efficacy of Vaccines
Vaccine Failure
Reverse Vaccinology
Vaccination Strategies
Safety of using Vaccines
Summary
References
Useful links
 
Chapter 15: Diagnostic Immunology
Immunoprecipitation Reactions
Agglutination Reactions
Complement Fixation Test (CFT)
Neutralization Reactions
Radioimmunoassay (RIA)
Enzyme Linked Immunosorbent Assay (ELISA)
Enzyme linked immunospot assay (ELISPOT assay)
Fluorescent Antibody Technique
Flow Cytometry
Immunohistochemistry
Western Blotting
Future Prospects
Summary
References
Useful links
 
List of Abbreviation

Bibliographic information

 Book Title: Fundamental Immunological Concepts

Publisher: ResearchersLinks

Authors/Editors: Faisal Rasheed Anjum, Sidra Anam, Sajjad ur Rahman, Muhammad Imran Arshad

Publication date: 2 May 2020

Total Pages: 165

Fundamental Immunological Concepts · ResearchersLinks