With rapid advancement in science and technology in the last few centuries, modifications in every aspect of life are continuously occurring. No doubt, these modifications are improving life standards but among them some are harmful for our health. Along with numerous benefits, side effects of formulated synthetic chemicals are needed to investigate further to develop alternatives with ideally no or at least less side effects. This review highlights a wide range of dermal disorders which are produced due to synthetic detergents. It has studied that ultimate solution of the grave issues, is common utilization of biosurfactants from domestic to industrial level. Biodetergents do not cause health complications, and as they are readily biodegradable so do not persist in environment. Our body’s protecting shield, the skin, has more chances of exposure and biodetergents have potential to eliminate the associated risk. Economical production of biosurface active substances at industrial level through utilization of bio-waste origin feedstocks would also enhance recycling and energy conservation in the environment. Through the application of biosustainable developments in the field of biotechnology, we would be able to get rid of various long lasting after effects of anthropogenic pollutants and synthetic detergents.