Infectious Bursal Disease Virus-Induced Chicken Innate Immune Genes Expression

Gabriela Mansano do Nascimento; Helena Lage Ferreira; Clarice Weis Arns

Mini-Review · Volume 4, Issue 1, 9 April 2017 · Open Access

Infectious Bursal Disease Virus-Induced Chicken Innate Immune Genes Expression

· ·

Affiliations & Notes ⌄

¹Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of Sao Paulo (FZEA-USP), Pirassununga, CEP 13635900, Brazil clarns@@gmail.com

Article Info ⌄

Journal:: Hosts and Viruses
Published:: 9 April 2017

Download PDF ePub eFLIP Set Alert Get Rights Reprints

From the article

Infectious Bursal Disease Virus-Induced Chicken Innate Immune Genes Expression.
Abstract | Infectious bursal disease virus (IBDV) belongs to the genus Avibirnavirus, a dsRNA virus that causes an acute, highly contagious and immunosuppressive disease in young chickens.
DF-1 cells overexpressing chMDA5 showed significantly higher expression of chicken MDA5, IRF-7, IFN-beta, PKR, OAS, Mx and MHC class I. Autophagy is also an essential component of the host innate immunity.
Infection and activation of bursal macrophages by virulent infectious bursal disease virus.

Selected from the article's own text.

Abstract

Infectious bursal disease virus (IBDV) belongs to the genus Avibirnavirus, a dsRNA virus that causes an acute, highly contagious and immunosuppressive disease in young chickens. The first line of defence against the virus is innate immunity whose activation is independent of the antigen and depends on the ability of the host to recognize pathogens by means of specific pattern recognition receptors. This interaction induces the production of cytokines, chemokines and interferons. Through Janus kinase/signal transducers and transcription activators pathway, interferon induces the transcription of interferon-stimulated genes (ISGs), responsible for playing an essential and decisive role in the virus pathology. Some studies have already reported the overexpression of these genes against IBDV infection in susceptible cells. The protection ability of ISGs to safeguard chicken cells against the virus could be potentially applied for vaccine production, better vaccination protocols and infection control in the future.

Acknowledgments

This study was funded by FAPESP (grant number: 2014/50696-4). CWA is recipient of fellowship from CNPq.

Conflict of Interest

All authors declare that they have no conflict of interest.

Authors’ Contribution

Conceptualization: CWA, HLF, Data curation: GMN, HLF, Formal analysis: GMN, HLF, CWA, Investigation: GMN, HLF, CWA, Methodology: GMN, HLF, CWA, Project administration: CWA, HLF, Funding acquisition: CWA.

References

Alkie, T.N., and S. Rautenschlein. 2016. Infectious bursal disease virus in poultry: current status and future prospects. Vet. Med. Res. Rep. 7: 9-18.
Hu, B., Y. Zhang, L. Jia, H. Wu, C. Fan, Y. Sun, C. Ye, M. Liao and J. Zhou. 2015. Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway. Autophagy. 11: 503-515. https://doi.org/10.1080/15548627.2015.1017184[CrossRef]
International Committee on Taxonomy of Viruses (ICTV). 2015. Virus Taxonomy Available at: http://ictvonline.org/subcommittee.asp?se=5&committee=155 (accessed: 23 Nov, 2016)
Khatri, M., J.M. Palmquist, R.M. Cha and J.M. Sharma. 2005. Infection and activation of bursal macrophages by virulent infectious bursal disease virus. Virus Res. 113: 44-50. https://doi.org/10.1016/j.virusres.2005.04.014[CrossRef]
Khatri, M., and J.M. Sharma. 2006. Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways. Virus Res. 118: 70-77. https://doi.org/10.1016/j.virusres.2005.11.015[CrossRef]
Kogut M.H., C. Swaggerty, H. He, I. Pevzner and P. Kaiser. 2006. Toll-like receptor agonists stimulate differential functional activation and cytokine and chemokine gene expression in heterophils isolated from chickens with differential innate responses. Microbes Infect. 8: 1866-1874. https://doi.org/10.1016/j.micinf.2006.02.026[CrossRef]
Lee, C.C., C.C. Wu and T.L. Lin. 2014. Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity. Arch. Virol. 159: 1671-1686. https://doi.org/10.1007/s00705-014-1983-9[CrossRef]
Lin, T.W., C.W. Lo, S.Y. Lai, R.J. Fan, C.J. Lo, Y.M. Chou, R. Thiruvengadam, A.H. Wang and M.Y. Wang. 2007. Chicken heat shock protein 90 is a component of the putative cellular receptor complex of infectious bursal disease virus. J. Virol. 81: 8730-8741. https://doi.org/10.1128/JVI.00332-07[CrossRef]
Mertens, P. 2004. The dsRNA viruses. Virus Res. 101: 3-13. https://doi.org/10.1016/j.virusres.2003.12.002[CrossRef]
Rasoli, M., S.K. Yeap, S.W. Tan, K. Roohani, Y.W. Kristeen-Teo, N.B. Alitheen, Y.A. Rahaman, I. Aini, M.H. Bejo, P. Kaiser and A.R. Omar. 2015. Differential modulation of immune response and cytokine profiles in the bursae and spleen of chickens infected with very virulent infectious bursal disease vírus. BMC Vet. Res. 11: 75. https://doi.org/10.1186/s12917-015-0377-x[CrossRef]
Sharma, J.M., I.J. Kim, S. Rautenschlein and H.Y. Yeh. 2000. Infectious bursal disease virus of chickens: pathogenesis and immunosuppression. Develop. Compar. Immunol. 24: 223-235. https://doi.org/10.1016/S0145-305X(99)00074-9[CrossRef]
Wang, Y., H. Sun, P. Shen, X. Zhang, X. Xia and B. Xia. 2010. Effective inhibition of replication of infectious bursal disease virus by miRNAs delivered by vectors and targeting the VP2 gene. J. Virol. Methods. 165: 127-132. https://doi.org/10.1016/j.jviromet.2008.12.022[CrossRef]

Services

Article usage statistics

Loading…

[1] Alkie, T.N., and S. Rautenschlein. 2016. Infectious bursal disease virus in poultry: current status and future prospects. Vet. Med. Res. Rep. 7: 9-18.

[2] Hu, B., Y. Zhang, L. Jia, H. Wu, C. Fan, Y. Sun, C. Ye, M. Liao and J. Zhou. 2015. Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway. Autophagy. 11: 503-515. https://doi.org/10.1080/15548627.2015.1017184[CrossRef]

[3] International Committee on Taxonomy of Viruses (ICTV). 2015. Virus Taxonomy Available at: http://ictvonline.org/subcommittee.asp?se=5&committee=155 (accessed: 23 Nov, 2016)

[4] Khatri, M., J.M. Palmquist, R.M. Cha and J.M. Sharma. 2005. Infection and activation of bursal macrophages by virulent infectious bursal disease virus. Virus Res. 113: 44-50. https://doi.org/10.1016/j.virusres.2005.04.014[CrossRef]

[5] Khatri, M., and J.M. Sharma. 2006. Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways. Virus Res. 118: 70-77. https://doi.org/10.1016/j.virusres.2005.11.015[CrossRef]

[6] Kogut M.H., C. Swaggerty, H. He, I. Pevzner and P. Kaiser. 2006. Toll-like receptor agonists stimulate differential functional activation and cytokine and chemokine gene expression in heterophils isolated from chickens with differential innate responses. Microbes Infect. 8: 1866-1874. https://doi.org/10.1016/j.micinf.2006.02.026[CrossRef]

[7] Lee, C.C., C.C. Wu and T.L. Lin. 2014. Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity. Arch. Virol. 159: 1671-1686. https://doi.org/10.1007/s00705-014-1983-9[CrossRef]

[8] Lin, T.W., C.W. Lo, S.Y. Lai, R.J. Fan, C.J. Lo, Y.M. Chou, R. Thiruvengadam, A.H. Wang and M.Y. Wang. 2007. Chicken heat shock protein 90 is a component of the putative cellular receptor complex of infectious bursal disease virus. J. Virol. 81: 8730-8741. https://doi.org/10.1128/JVI.00332-07[CrossRef]

[9] Mertens, P. 2004. The dsRNA viruses. Virus Res. 101: 3-13. https://doi.org/10.1016/j.virusres.2003.12.002[CrossRef]

[10] Rasoli, M., S.K. Yeap, S.W. Tan, K. Roohani, Y.W. Kristeen-Teo, N.B. Alitheen, Y.A. Rahaman, I. Aini, M.H. Bejo, P. Kaiser and A.R. Omar. 2015. Differential modulation of immune response and cytokine profiles in the bursae and spleen of chickens infected with very virulent infectious bursal disease vírus. BMC Vet. Res. 11: 75. https://doi.org/10.1186/s12917-015-0377-x[CrossRef]

[11] Sharma, J.M., I.J. Kim, S. Rautenschlein and H.Y. Yeh. 2000. Infectious bursal disease virus of chickens: pathogenesis and immunosuppression. Develop. Compar. Immunol. 24: 223-235. https://doi.org/10.1016/S0145-305X(99)00074-9[CrossRef]

[12] Wang, Y., H. Sun, P. Shen, X. Zhang, X. Xia and B. Xia. 2010. Effective inhibition of replication of infectious bursal disease virus by miRNAs delivered by vectors and targeting the VP2 gene. J. Virol. Methods. 165: 127-132. https://doi.org/10.1016/j.jviromet.2008.12.022[CrossRef]