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Case Report · Volume 4, Issue 1, Pages 1–4, 22 November 2015 · Open Access

A Case Report on Invasive Ductal Carcinoma in Dog

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Journal:
Advances in Animal and Veterinary Sciences
Published:
22 November 2015
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From the article

  • Keywords | Invasive ductal carcinoma, Dog, ER, HER2/neu, Mammary gland.
  • Tumours of the mammary gland are among the most common neoplasms in the dog, but little is known about familial canine neoplasia.
  • Studies have shown that several non-neoplastic mammary intraepithelial lesions have been associated with the development of invasive mammary carcinomas.
  • HER-2 and EGFR overexpression was associated with malignancy in canine mammary tumors.

Selected from the article's own text.

Abstract

Tofazzal Md. Rakib1*, Md. Shafiqul Islam1, Mohammad Mahbubur Rahman1, Amam Zonaed Siddiki1, Bibek Chandra Sutradhar2, Mohammad Alamgir Hossain1, Md. Masuduzzaman1

1Department of Pathology and Parasitology; 2Department of Medicine and Surgery, Chittagong Veterinary and Animal Sciences University, Chittagong, Bangladesh.

*Correspondence | Tofazzal Md. Rakib, Chittagong Veterinary and Animal Sciences University, Zakir Hossain Road, Khulshi-4225, Chittagong, Bangladesh; E-mail: rakibtofazzal367@gmail.com

Abstract
Invasive ductal carcinoma is the most common invasive breast cancer in both women and pets, while the mammary tumors are the second most frequent neoplasm in dogs. A 5 years old bitch was presented at Teaching Veterinary Hospital of Chittagong Veterinary and Animal Sciences University, Bangladesh, having hard lump with irregular borders at post umbilical region. The biopsy sample was taken followed by histopathology and ER, HER2/neu, Ki67 immunostaining was done to know the type and cell origin of the tumour. Pleomorphism, increased mitotic figure and metastasis were revealed in histopathology. The section gave higher response to ER, HER2/neu Ig where response to Ki67 was low indicating luminal type A invasive ductal carcinoma. Grading tumours by immunostaining aid in prognosis and therapy.

Keywords | Invasive ductal carcinoma, Dog, ER, HER2/neu, Mammary gland

Editor | Kuldeep Dhama, Indian Veterinary Research Institute, Uttar Pradesh, India.

Received | August 30, 2015; Revised | September 30, 2015; Accepted | October 01, 2015; Published | November 22, 2015

Citation | Rakib TM, Islam MS, Rahman MM, Siddiki AZ, Sutradhar BC, Hossain MA, Masuduzzaman M (2016). A case report on invasive ductal carcinoma in dog. Adv. Anim. Vet. Sci. 4(1): 1-4.

ISSN (Online) | 2307-8316; ISSN (Print) | 2309-3331

Copyright © 2016 Rakib et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

Acknowledgement

The author would like to thank Dr. Sharmin Chowdhury (Professor, Dept. of Pathology and Parasitology, CVASU) for providing financial support to complete the research work from HEQEP project (HEQEP CP: 3220); author would also like to thank Dr. Md. Zillur Rahman, Associate Professor, Department of Pathology, Chittagong Medical College, Bangladesh for providing technical support throughout the investigation process.

aUTHORS’ CONTRIBUTION

All the authors contributed equally.

Conflict of interest

There exisis no conflict of interest.

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