SOD value result from influence of that berberine and enerofloxacin against E. coli infection induced in poultry chicks. NCG: Negative control group T1: Inoculated with 6x108 CFU/ml of E. coli. T2: Inoculated with 6x108 CFU/ml of E. coli treated by enrofloxacin. T3 group: Inoculated with 6x108 CFU/ml of E. coli and were treated with BBR.T4 group: Inoculated with 6x108 CFU/ml of E. coli and were treated with both combination enrofloxacin and BBR.