Proteolytic activation by breaking R561-V562 bond (a) Green color full-length plasminogen (plg) and SK superposition where SK covered the plasminogen catalytic domain. (b) Clear picture of plg activation domain of O-linked glycan on T346. (c) streptokinase-plasminogen binding view without steric hindrance and in yellow colored sticks disulphide bonds are expressed (Law et al., 2012).