Different mechanisms of loading platinum-based drugs such as phen Pt and cisplatin into TMV a) Graphical abstract from Lippard, S.J., et al. showing the loading schematic for phenPt loading into wild-type TMV particles (reproduced with permission from ref (Vernekar et al., 2018b) Graphical illustration of the phenPt docking onto the Glu97 and Glu106 residues of TMV as discovered through matrix-assisted laser desorption/ionization–mass spectrometry and nuclear magnetic resonance spectroscopy c) Graphical schematic of the assembly of TMV spherical nanoparticles using a fluorous ponytail interaction (F-TMVCP). Cisplatin was loaded into the F-TMVCP using the same glutamic residues as in b (not shown) (reproduced with permission from ref (Gao et al., 2018).