(A) BHD treatment inhibited STZ-induced apoptosis pathway in rats with DM. The density of PI3K, p-PI3K, AKT, p-AKT, Bax, Bcl-2, and Caspase-3 were measured by Western Blot. (B) Quantitative data of PI3K, (C) p-PI3K, (D) AKT, (E) p-AKT, (F) Bax, (G) Bcl-2, (H) Bax/Bcl-2, (I) Caspase-3, and (J) Cleaved Caspase-3 are presented. Data are shown as mean ± SD (n=3). ** P <0.01, vs. the control group; ## P < 0.01, vs. the DM group.