Effect of CAPE and/or CNPs on the Global DNA methylation quantities in HepG2 cells. Cells were treated with CAPE and CNPs alone or in combination (CAPE+CNPs) at doses of their IC50 and incubated for 72 h. Data were presented in the form of % mean ± SEM, n = 5/group. Different letters above means (as presented by columns plus error bars) refer to significant differences at P<0.05. All groups compared to each other. The control group was assigned a value of 100%.