Effect of BHD on representative microscopical images of cerebral hippocampus (A), showing CA1 region from each group, (B) number of Bax, Bcl-2 (C), Bax/Bcl-2 (D), caspase-3 positive cells/field (E). Tissue sections of cerebral hippocampus CA1 region were stained with H & E and IHC (×200 magnification). ** P <0.01, vs. the control group; ## P < 0.01, vs. the DM group.