A, Pie chart of retrieved validated SNPs of APOB from NCBI and Ensembl data bases. It includes 295 (62%) missense, 170 (36%) intronic, 4 (1%) 3′ UTR and 5 (1%) 5′-UTR. B, Convergent deleterious and functionally important SNPs are located in distinct exonic region of APOB gene. The 3’ and 5’ un-translated regions are represented by hatched bars and the exons are represented by filled bars. The APOB amino acid position is relative to Gene Bank Accession number NC_000002. 12.