The effect of LY6K knockdown in A549 cells on tumor formation was observed in subcutaneous tumor carrying experiment in nude mice. A, Tumor growth curves of si-NC group and si-LY6K group, ** p <0.01; B-C, Tumor weight in the si-NC group and the si-LY6K group, ** p <0.01; D, Expression of LY6K, GLUT1, HK2, PFKL, ALDOA, PGK-1, PKM2 and LDHA in subcutaneous tumor tissue of nude mice in si-NC group and si-LY6K group, * p <0.05.