Effect of ATO on serum insulin (A), insulin resistance (B), bloood glucose level (C) and HbA1c level (D). Significance was estimated by Bonferroni post-test using one way ANOVA. * represents P < 0.05, ** represents P < 0.01 and ns represents non-significant when compared with NC group. ATO, arsenic trioxide group; HbA1c, hemoglobin A1c; MF, metformin group; NC, normal control group; RSV, resveratrol group.