(A) Creation of circular full-thickness skin wound with 2 cm in diameter. (B) Shows a cylindrical metal tube with sharp end used for induce circular wound. (C) The induced infected wound. (D) Shows the infected wound after cleaning and debridement. (E) Application of SIS hydrogel on wound area. (F) Application of SIS hydrogel- AgNPs composite on wound area. (G) Shows covering of the wounds by Tegaderm in GI, GII and GIII. (H) Measurement of three different diameters of wound using a Vernier caliper.