Pancrease in adult dog (H&E stain) in (A) Negative control group (non diabetic, not treated) showing normal tissue. (B) Positive control group (diabetic, saline treated) induced by alloxan–nicotinamide showing pancreatic damage. (C) Ginger ethanolic extract (GEE) group (diabetic, treated with 81.7 mg/kg BW GEE for 6 weeks) showing. (D) GEE-chitosan nanoparticles (GEE-CNPs) group (diabetic, treated with 81.7 mg/kg BW GEE-CNPs) for 6 weeks) group showing. (E) CNPs group (diabetic, treated with 81.7 mg/kg BW CNPs) showing.