Post-ischemic treatment with sevoflurane may inhibit PTEN by up-regulating miR-26a-5p to activate the PI3K/Akt pathway. The effect of post-ischemic treatment with sevoflurane on PI3K/Akt signaling pathway (n=3) was detected by Western blot. ** represents sham group V.S. I/R model group; ## represents I/R model group V.S. sevoflurane group P<0.01; and represents sevoflurane group V.S. sevoflurane+antamiR-26a-5p group P<0.01.