A: Tio2 N.P. synthesis by Hypericin ؛ B: Calcium alginate pad (Nondiabetic rat)؛ C: Tio2 N.P. synthesis by Origanum vulgare; D: Tio2 N.P. synthesis by Hypericum perforatum; E: Methicillin; F: Calcium alginate pad (Diabetic rat); G: Tio2 N.P. synthesis by Carvacrol; H: Tio2 N.P. (Highest to lowest collagen density in different NPs treated rat A-H)